Defining secondary progressive multiple sclerosis

J Lorscheider; K Buzzard; V Jokubaitis; T Spelman; E Havrdova; D Horakova; M Trojano; G Izquierdo; M Girard; P Duquette; A Prat; A Lugaresi; F Grand'maison; P Grammond; R Hupperts; R Alroughani; P Sola; C Boz; E Pucci; J Lechner-Scott; R Bergamaschi; C Oreja-Guevara; G Iuliano; V Van Pesch; F Granella; C Ramo-Tello; D Spitaleri; T Petersen; M Slee; F Verheul; R Ampapa; MP Amato; P Mccombe; S Vucic; JL Sánchez Menoyo; E Cristiano; MH Barnett; S Hodgkinson; J Olascoaga; ML Saladino; O Gray; C Shaw; F Moore; H Butzkueven; T Kalincik

Journal article

Defining secondary progressive multiple sclerosis

J Lorscheider, K Buzzard, V Jokubaitis, T Spelman, E Havrdova, D Horakova, M Trojano, G Izquierdo, M Girard, P Duquette, A Prat, A Lugaresi, F Grand'maison, P Grammond, R Hupperts, R Alroughani, P Sola, C Boz, E Pucci, J Lechner-Scott Show all

Brain | SAGE PUBLICATIONS LTD | Published : 2016

DOI: 10.1093/brain/aww173

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Abstract

A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies. Using MSBase, a large, prospectively acquired, global cohort study, we analysed the accuracy of 576 data-derived onset definitions for secondary progressive multiple sclerosis and first compared these to a consensus opinion of three neurologists. All..

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University of Melbourne Researchers

Timothy Spelman Author

Tomas Kalincik Author

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CENTRE FOR TRANSLATIONAL NEUROSCIENCE: A MODULAR PLATFORM FOR TRANSLATING DISCOVERY INTO HEALTH OUTCOMES

Clinical Centre of Research Excellence in Translational Neuroscience will provide people, pathways and resources to create a novel platform ..

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While there are numerous therapies for relapsing-remitting multiple sclerosis (MS), therapy for progressive MS remains elusive. This project..

CENTRE FOR TRANSLATIONAL NEUROSCIENCE: A MODULAR PLATFORM FOR TRANSLATING DISCOVERY INTO HEALTH OUTCOMES

Clinical Centre of Research Excellence in Translational Neuroscience will provide people, pathways and resources to create a novel platform ..

Grants

Awarded by National Health and Medical Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This study was financially supported by the National Health and Medical Research Council (practitioner fellowship 1080518, project grants 1083539 and 1032484 and centre for research excellence 1001216), the University of Melbourne (Faculty of Medicine, Dentistry and Health Sciences research fellowship) and Biogen (Fellowship in MS Registries Research). The MSBase Foundation is a not-for-profit organization that receives support from Merck, Biogen, Novartis, Bayer-Schering, Genzyme, Teva and Sanofi-Aventis. The study was conducted separately and apart from the guidance of the sponsors.